POU5F1 and hepatocellular carcinoma: Furthermore, we clarified that the interaction between TROY and p85α could lead to p85α degradation and subsequently activate PI3K/AKT/TBX3 signaling, which helps to maintain the pluripotency of liver CSCs by upregulating the expression of SOX2, NANOG, and OCT4 and promote cell motility via activating EMT pathway in HCC.