The role of extracellular HMGB1 on breast cancer progression via promoting cancer cell migration and invasion herein was supported by the recent reports showing that downregulation of miR-205 contributes to epithelial-mesenchymal transition (EMT) and invasion in triple-negative breast cancer by targeting the HMGB1-RAGE signaling pathway [19]. This evidence concerns the gene HMGB1 and breast cancer.