Various HCC staging systems are used to clinically guide HCC treatment, such as Okuda system, Tumor, Node, Metastasis (TNM) staging, Cancer of the Liver Italian Program (CLIP) score, Barcelona staging classification (BCLC), Albumin-Bilirubin (ALBI) score, etc. [64–68]. The gene discussed is ALB; the disease is hepatocellular carcinoma.