TPI1 and esophageal squamous cell carcinoma: The protein expression of glycolysis increased in ESCC patients (Fig. 6B), and among them, shown by Pearson correlation analysis, levels of ENO1, PGAM1, TPI1, PKM, PGK1, ALDOA and LDHB were positively correlated with clinicopathological TNM stages (R2 = 0.59, P = 6.53e−7, R2 = 0.46, P = 3.99e−5, R2 = 0.33, P = 9.1e−4, R2 = 0.31, P = 0.001, R2 = 0.37, P = 3.7e−4, R2 = 0.34, P = 7.0e−4, and R2 = 0.39, P = 1.8e−4, respectively) (Fig. 9A).