Acrophase estimates for light-entrained diurnal and circadian wheel running rhythms did not differ between young RCAN1 TG or Dp16 mice and WT controls, indicating that elevated RCAN1 levels do not contribute to the circadian phase shifts observed in DS, AD, aging individuals, or animal models thereof [25, 31, 40, 56, 67]. Here, RCAN1 is linked to Alzheimer disease.