Including MGMT methylation with the clinical variables yielded a 14.2% reduction in prediction error with respect to the reference IBS, integrating radiomics with clinical data resulted in 15% decrease, a combination of clinical, MGMT methylation, and radiomics achieved 19.4% decrease in prediction error, similar to an integration of clinical, MGMT methylation, and genetics with 19.8% decline in IBS. Here, MGMT is linked to irritable bowel syndrome.