AT8 is used to classify the neurofibrillary degeneration into stages known as the Braak stages39.The results indicate that the presence of somatodendritic phospho-tau is associated with variety of alterations in the length and/or position of the AIS, which might contribute to changes in the activity of neuronal circuits in tauopathies. The gene discussed is MAPT; the disease is tauopathy.