PLK1 and cancer: Of these DEGs, 6 (EGFR, GATA3, DIABLO, CFLAR, RIPK3, and MAPK8) were repressed, while (ZBP1, PLK1, SPATA2, BCL2, ALK, FASLG, TNFRSF21, and LEF1) were upregulated in cancer cases (Fig. 1D).