It has been argued that DNA damage is one of the most important drivers of aging.3,22,23 A previous report showed that chromodomain helicase DNA-binding protein 4 (CHD4), a key component of the nucleosome remodeling and histone deacetylation (NuRD) complex plays a central role in DNA damage-repair mediated gene silencing in cancer cells.24 Therefore, we hypothesized that age-related DNA methylation could also be mediated by DNA damage and its repair process. This evidence concerns the gene CHD4 and cancer.