ELOVL2 and diabetes mellitus: Intriguingly, Elovl2, a gene which functions as a master control of lipid metabolism and is strongly associated with diabetes, shows the most relevance to aging.4,11,15,16 Slieker et al. claimed that ELOVL2 is a unique tissue-independent age-associated DNA methylation marker,15 however, a subsequent report showed that ELOVL2 is not a unique universal aging marker and that there are many more CpG sites/genes that are consistently altered with age across many different cell/tissue types.