ELOVL2 and neurodegenerative disease: it’s been reported that restoration of mitochondrial function by NAD+ precursor nicotinamide (vitamin B3) was protective both prophylactically and as an intervention against Glaucoma, a neurodegenerative diseases that cause vision loss, especially in the elderly.40 To further confirm whether restoration of mitochondria can rescue AMD phenotype in Elovl2 Knockdown RPE cells, we treat the Elovl2 knockdown RPE cells with nicotinamide (Ni).