Two additional cases with lower H:C index were diagnosed to have hippocampal sclerosis, which is known to correlate well with TDP-43 pathology.16,24 Five of 6 cases with relatively higher H:C index (toward hippocampal-sparing AD) were assigned to have amygdala-predominant LB pathology, a distinct pathologic entity.4 Whether/how the presence of LB pathology in the amygdala plays a role in the disposition of the hippocampal-sparing AD atrophy subtype to the pathology remains to be seen. Here, TARDBP is linked to Alzheimer disease.