TARDBP and Alzheimer disease: The limbic-predominant AD tau subtype has been described to be more prone to exhibiting TDP-43 in previous postmortem studies.16,24,26 It is thus plausible for the limbic-predominant AD atrophy subtype to follow suit, given the topographical similarity between tau and atrophy patterns in limbic-predominant AD.15 Congruent with the report from the recent meta-analysis,7 our study provides an antemortem-to-postmortem validation and evidence supporting the association of the limbic-predominant AD atrophy subtype with TDP-43.