CRK and breast cancer: In addition, CCL18 can bind with PITPNM3, inducing EMT, migration, and invasion of non-small cell lung cancer and breast cancer via PI3K/Akt/GSK3β/Snail signaling pathway and engulfment and cell motility 1/dedicator of cytokinesis protein 4 CRK binding protein signaling pathway, respectively [5,6].