There is interestin developing HDPs for therapeutic use as part of the response tothe global increase in antimicrobial resistance, with some peptidesable to combat infections by influencing the host immune responseand antimicrobial peptides (AMPs) possessing highly potent bactericidalactivity.1 Because of this and because,unlike clinically relevant antibiotics, HDPs and AMPs are producedby metazoans to counter infections, there is also interest in understandinghow they have remained effective throughout evolutionary history.2 Here, ADSL is linked to infection.