In the current research, a large number of bioinformatic analysis tools have been used to identify five hub genes (TRIM22, IFI6, IFITM1, IFI35, and IRF9) between PM/DM and health control subjects on the basis of gene expression profiles attained from GSE1551 (DM), GSE3112 (PM), GSE39454 (DM), GSE39454 (PM), GSE46239 (DM), GSE128470 (DM), and GSE128470 (PM) datasets. This evidence concerns the gene IFI6 and dermatomyositis.