Because colonic Treg cells expressed P2ry10 (Fig. S4 A) and LysoPS affected glycolytic metabolism in in vitro–skewed Treg cells (Fig. 6 F), we analyzed the impact of LysoPS on the suppressive activity of Treg cells in this colitis model (Fig. 8, E–G). This evidence concerns the gene P2RY10 and colitis.