SLC26A3 and Hyperoxaluria: Here, we report inhibition of SLC26A3-mediated oxalate transport in cells and mouse intestine by lead candidate DRAinh-A270 (compound 4az in ref. 19; structure shown in Figure 1A) and efficacy in reducing urinary oxalate excretion and prevention of renal calcium oxalate crystal deposition and renal injury in mouse models of hyperoxaluria and oxalate nephropathy.