HDAC2 and colon adenoma: Inhibition of class I HDACs with the histone deacetylase inhibitor (HDACi) valproic acid (VPA) and a consequently accelerated proteasomal degradation of HDAC2 (Krämer et al. 2003) could block colonic adenoma formation in mice (Zhu et al. 2004), underscoring the relevance of HDAC2.