In multivariable models (Table 3), Black women had relative under-expression of AKT1 (log2 fold-change = − 0.31, 95% CI − 0.44, -0.18) and RPS6KB2 (log2 fold-change = − 0.11, 95% CI − 0.19, − 0.03) in their breast tumors compared to White women. This evidence concerns the gene RPS6KB2 and breast neoplasm.