Using autopsied brain tissue from the ROSMAP with multi-region brain transcriptomes, higher expression of FMNL2 was associated with pathological AD in all three regions sampled: the dorsolateral prefrontal cortex (p = 0.004), the posterior cingulate cortex (p = 0.001) and in the anterior caudate (p = 0.012). This evidence concerns the gene FMNL2 and Alzheimer disease.