Mutations in the destruction complex proteins, especiallyin APC, are frequent in cancers, and therefore, TNKS inhibitors couldbe used as a therapy for treating a range of cancers60 including colon,61 lung,62 liver,63 ovarian,64 and brain.65 Anotheressential role of these enzymes is explicated in the Hippo signaling.Indeed, they promote the activity of the oncoprotein YAP by suppressingthe antagonist angiomotin (AMOT) family proteins involved in the YAPdegradation. Here, AMOT is linked to cancer.