PARP14is overexpressed in a series of cancers such as diffuse large B celllymphoma (DLBCL),108 multiple myeloma,109 prostate cancer,110 and hepatocellular carcinoma (HCC).111 The multiple roles of PARP14 in cancer have been recently reviewed.112 In cancer cell lines, the overexpressed PARP14promotes the transcription of genes involved in the growth and cancerproliferation due to its modulation of the IL-4-STAT6 signaling pathway.Indeed, in the absence of IL-4, PARP14 binds the gene promoter andsilences the transcription. The gene discussed is STAT6; the disease is hepatocellular carcinoma.