GH1 and malnutrition: In reality, sustained inflammation, steroid treatment, and malnutrition contribute to decreased growth rate and increased cytokine production, and growth hormone insensitivity might be a major mechanism involved in either growth retardation or sarcopenia.[34] Reduction of inflammation through accelerated top-down treatment using biologics can be the cornerstone of treatment, and restoring sarcopenia with these modalities might be a successful therapeutic plan, although more research is required.