The metabolite α-ketoglutarate was also suggested to cause caspase-8-mediated GSDMC processing and pyroptosis in cancer cells via death receptor-6 signaling, although in this case GSDMC expression was beneficial in decreasing tumor size and metastasis (following α-ketoglutarate treatment) in murine xenograft cancer models [130]. The gene discussed is CASP8; the disease is cancer.