TNF and cancer: Interestingly, IFNγ, type I IFNs and to a lesser extent TNF, could induce GSDMB expression in some cancer cell lines, and IFNγ treatment could thereby confer susceptibility to Granzyme A-driven pyroptosis in vitro, while the expression of GSDMB in tumor cells facilitated tumor clearance in vivo following immune checkpoint blockade [132].