Recent findings also correlate GSDME levels and activation in patient intestinal mucosa or synovial immune cells with Crohn's disease and rheumatoid arthritis severity, respectively, and mice deficient in GSDME were protected from chemical-induced (2,4,6-trinitrobenzenesulfonic acid) colitis or collagen-induced arthritis [125,126]. This evidence concerns the gene GSDME and Crohn disease.