KCNMA1 and Parkinson disease: As the large conductance Slo1 K+ channel, whose K+ permeation rate is several orders of magnitude higher than TMEM175, has also been observed in lysosomes, it will be important to uncover the specific roles for TMEM175’s distinct conduction and selectivity properties in the lysosome and why mutations of TMEM175 can both increase and decrease the likelihood of developing PD (Wang et al., 2017; Zhong et al., 2016).