Dysregulation of lysosomal function is commonly associated with neurodegenerative disease and point mutations in TMEM175 have been identified that are strongly associated with development of Parkinson’s disease (PD) (Blauwendraat et al., 2019; Iwaki et al., 2019; Jinn et al., 2019; Jinn et al., 2017; Krohn et al., 2020; Nalls et al., 2014; Wie et al., 2021). The gene discussed is TMEM175; the disease is Parkinson disease.