PIEZO1 and esophageal squamous cell carcinoma: This research, by performing membrane proteome screening and validation, has found that the Piezo‐Type Mechanosensitive Ion Channel Component 1 (PIEZO1) is significantly overexpressed in a large proportion (50%) of ESCC patients, and tumor cell surface located PIEZO1 can be internalized with the binding of its monoclonal antibody.