In contrast, the other two cell lines, especially Kyse150, which had lower expression and less cell surface enrichment of PIEZO1, were more resistant to Anti‐PIEZO1‐MMAE treatment than TE‐1, suggesting ESCC cells with higher cell surface PIEZO1 expression were more sensitive to Anti‐PIEZO1‐MMAE treatment (Figure 3D,E). Here, PIEZO1 is linked to esophageal squamous cell carcinoma.