Outcomes of C + I observed in our study were well correlated with previous observations reported worldwide, indicating a limited activity of ICI for NSCLC patients with EGFR ex20ins.8, 10, 12, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.