However, in response to AngII challenge, premenopausal women in the high estradiol phase demonstrated both a decrease in LF (ΔLF = −0.07 ± 0.46 ln ms2, p = 0.048, time 60 min vs. baseline) and HF (ΔHF = −0.33 ± 0.74 ln ms2, p = 0.048, time 60 min vs. baseline), though no change in overall LF:HF was observed (p = 0.86) (Table 4, Figure 2) In contrast, no changes in LF (p = 0.6), HF (p = 0.2) or LF:HF (p = 0.3) (all values time 60 min compared to baseline) in response to AngII challenge were observed in the low estradiol phase. The gene discussed is AGT; the disease is hydrops fetalis.