Emerging evidence has shown that RNA molecules and proteins could affect the interaction between DUSP6 and MAPK1.24, 25 Consistent with these observations, we revealed that GK‐IT1 was involved in the aberrant activation of the ERK/MAPK pathway by attenuating the interaction between MAPK1 and DUSP6, thereby suppressing DUSP6‐mediated dephosphorylation of MAPK1 and facilitating the malignant progression of ESCC. This evidence concerns the gene DUSP6 and esophageal squamous cell carcinoma.