GK-IT1 and esophageal squamous cell carcinoma: To probe the potential biological roles of GK‐IT1 in ESCC, we constructed an overexpression plasmid for GK‐IT1 and designed three siRNAs that target the gene sequences of GK‐IT1 to establish GK‐IT1 gain‐of‐function and loss‐of‐function cell models of ESCC, respectively.