Dysregulation of the extracellular signal‐regulated kinase/mitogen‐activated protein kinase (ERK/MAPK) signaling pathway has been widely implicated in a range of human diseases, including cancers.19, 20 Canonically, upstream kinases mediate the activation of the ERK/MAPK pathway, which may further regulate many cellular biological processes, including proliferation, differentiation, and transformation.21 The gene discussed is MAPK1; the disease is cancer.