LINC00858 and urinary bladder cancer: It has been reported that lncRNAs could regulate gene expression through multiple mechanisms, such as epigenetic, transcriptional, and chromatin regulation.39, 40 For example, LNMAT2 epigenetically upregulates PROX1 expression by recruiting hnRNPA2B1 and increasing the H3K4 trimethylation level of the PROX1 promoter in bladder cancer.41