Citalopram was also added for comparison dueto its greater selectivity for the 5-HT transporter than paroxetine and itsshort half-life in rodents (Fredricson Overø, 1982).Anxiety-like behaviours were measured using a battery of tests, includingthe elevated plus maze (EPM), which has proven sensitive in detecting thewithdrawal states of other drugs (El Hage et al., 2012; Emmett-Oglesby et al.,1990; Perez and De Biasi, 2015; Vuong et al., 2010) and ishighly sensitive to manipulations of the 5-HT system (Briley et al., 1990; Handley and McBlane,1993; Ohmura et al., 2020). The gene discussed is SLC6A4; the disease is Anxiety.