In addition to promoting angiogenesis [66], enhancing osteoclastogenesis, receptor activator of nuclear factor-kB ligand expression in fibroblast-like synoviocytes [67], intensifying matrix metalloproteinase-3 and IL-6 in RA cartilage progenitor cells [68], IL-17 is used to assess radiographic progression in patients with RA [69], C-reactive protein (CRP), anti-cyclic citrullinated peptide antibody, histopathological alterations [70], and treatment efficacy [71]. This evidence concerns the gene MMP3 and rheumatoid arthritis.