HIF-1α regulated numerous physiological functions and even tumorigenesis in the hypoxic tumor microenvironment (TME) [13, 14] and modulated the tumor development and survival by involving in the tumor cell apoptosis, cell proliferation, differentiation, or migration, which serves a crucial role in the progression of breast, esophageal, lung, prostate, colon, and liver cancer [15–17]. The gene discussed is HIF1A; the disease is neoplasm.