Previous studies demonstrated that 14-3-3β, which is considered as an oncogene and serves a crucial role in tumor angiogenesis and tumor formation, can modulate tumor cell proliferation, motility, cycle, and apoptosis via specific stimulator factors or downstream pathways, including mitogen-activated protein kinase- (MAPK-) dependent signal activation [37, 38]. This evidence concerns the gene WNK2 and neoplasm.