Mutations in Ski2 and Ski3 cause the intestinal and immune disorder, trichohepatoenteric syndrome (THES) by an unknown pathogenic mechanism (Bourgeois et al. 2018; Fabre et al. 2012; Hartley et al. 2010; Morton et al. 2018). The gene discussed is SKIC2; the disease is Syndromic diarrhea.