Mechanistically, we found that TAMs-exo-contained H19 interrupted the interaction between autophagy-promoting protein Unc-51 such as autophagy-activating kinase 1 (ULK1) and its specific E3 ligase NEDD4-like E3 ubiquitin protein ligase (NEDD4L), therefore promoting ULK1 stabilization-induced abnormal activation of autophagy in BC cells, and our findings suggested exosomal lncRNA H19 derived from TAMs as a potential target for the treatment of BC. Here, UBE2E3 is linked to breast cancer.