Conversely, M2-like TAMs-derived exosomes could facilitate HCC metastasis by transferring αmβ2 integrin to tumor cells [19], and TAMs exosomal microRNA-501-3p contributes to the progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway [20]. Here, TGFBR3 is linked to neoplasm.