Thus, due to the involvement of CS in alteration of DNA methylation status [39, 40], and in hampering the expression of EYA4 in lung tissues taken from smokers compared to nonsmokers [27] as well as the impact of DNA methylation in depleting EYA4 expression in oral [41] and colon cancer [31], we suggest that CS could have a role in changing the methylation status of EYA4 in Saudi population. This evidence concerns the gene EYA4 and colonic neoplasm.