IGFBP4 and melanoma: In the metastasis signature, Arnt2 and Igfbp4 genes, highly expressed (Fig. 8A) and hypomethylated (Fig. 8B) only in 4C11 + metastatic melanoma cells compared to melan-a, 4C and 4C11− cells, had their expression significantly increased in melan-a, 4C and 4C11− cells after 5azaCdR and 5azaCdR + TSA treatment (Fig. 8C).