PPFIBP2 and neoplasm: On the other hand, cg01607369, which is located in the gene body of PPFIBP2, and an open sea region, had an HR of 0.3 in the malignancy but a HR equal of 2.9 in the metastasis signature; it may be concluded that its methylation status is associated with better prognosis during tumor initiation but with worse prognosis at the metastatic state.