SHANK3 and type 2 diabetes mellitus: Though not statistically significant after adjustment for multiple comparisons, the top-ranking pathways enriched in the overlapping genes include “Glutamatergic synapse” (ADCY5/ADCY7/GRIK4/PLA2G4A/PLCB1/SHANK2/SHANK3/SLC1A6, P value = 5.32e-06), “cortisol synthesis and secretion” (ADCY5/ADCY7/LDLR/PLCB1, P value = 2.29e-03), “insulin secretion” (ADCY5/ADCY7/PLCB1/RYR2, P value = 6.28e-3), “insulin signaling pathway” (HK2/PRKCZ/SH2B2/SHC2/SOCS3, P value = 6.34e-3), “type II diabetes” (HK2/PRKCZ/SOCS3, P value = 7.10e-3) and “bile secretion” (ADCY5/ADCY7/LDLR, P value = 0.040) (Fig. 2E).