Interestingly, we noticed that the four regulators with the highest mutation frequency in colon cancer, namely KMT2D (64/399, 16.0%), KMT2B (52/399, 13.0%), KMT2C (48/399, 12.0%), and SETD1B (46/399, 11.5%), were all histone H3 lysine 4 (H3K4) methyltransferases that belonged to the “Complex of Proteins Associated with Set1” family [13]. The gene discussed is KMT2D; the disease is malignant colon neoplasm.