Furthermore, tumor microenvironment (TME) analyses revealed significantly higher immune cell infiltration abundance, especially for cytotoxic cells, CD8+ T cells, activated dendritic cells, and Th2 cells, in samples from patients with mutations in any one of KMT2D, KMT2B, KMT2C, or SETD1B than in samples from patients without these mutations (Additional file 2: Fig. S1E). Here, CD8A is linked to neoplasm.