The finding that asthma-associated SNPs in the class II region were associated with increased HLA-DQA2 and HLA-DQB2 expression is consistent with our earlier results showing that predicted increased expression of HLA-DQA2 and HLA-DQB2 [65] was among the most significant gene-based associations with asthma risk [3]. The gene discussed is HLA-DQB2; the disease is asthma.