Likewise, several components of the complement system (C1, C2, C3, C4 and C7) showed the same abundance behavior as described above, whereas further complement components (C5, C8, C9 and complement factor B) revealed a different kinetic with a steeper decrease after ALS and a flattening of the decrease during CARL (Fig. 4c). Here, C5 is linked to amyotrophic lateral sclerosis.