NRG1 and dementia: In this study, we report that plasma synaptic marker NRG1 (i) was increased in AD patients already at the MCI stage; (ii) had a promising AUC to discriminate AD patients both at MCI and dementia stage, from NC; (iii) was associated with CSF AD biomarkers in Aβ-positive individuals; (iv) correlated with CSF synaptic markers; and (v) was inversely correlated with cognition.