TIM3- and PD-1-positive cells among CD8+ T populations of LN#12 and 20 were higher than in those of LN#21 and LN#23, LN#26 and LN#28 of C207 which showed tumor-reactivity (Fig. 2c and Additional file 2: Fig. S2b). The gene discussed is HAVCR2; the disease is neoplasm.