These studies include determining the efficacy of baricitinib in patients with inadequate responses to methotrexate [18], comparing baricitinib with methotrexate in patients beginning therapy with disease-modifying agents (RA-BEGIN) [19], the use of baricitinib in patients who were intolerant to DMARDS (RA-Build) [20], baricitinib compared to anti-TNFα therapy (RA-BEAM) [13] and the efficacy of baricitinib in patients with moderate to severe RA with an inadequate response to anti-TNFα therapy (RA-Beacon) [12]. This evidence concerns the gene TNF and rheumatoid arthritis.