On the other hand, while non-mutant glioblastoma-associated antigens (GAAs), such as ephrin type A receptor 2 (EphA2) and IL13Rα2, are more uniformly expressed in GBM, they are also expressed in some non − CNS organs (https://www.proteinatlas.org), raising a concern of off-tumor toxicity outside of CNS. This evidence concerns the gene IL13RA2 and glioblastoma.