EPHA2 and glioblastoma: In this system, the first antigen, which is expressed exclusively on GBM cells (eg, EGFRvIII) or in the brain (e.g., myelin oligodendrocyte glycoprotein [MOG]), primes the T cells to induce expression of a CAR that recognizes EphA2 and IL13Rα2, thereby eradicating GBM cells expressing either EphA2 or IL13Rα2.