Inflammatory-response cell subpopulations that participate in anti-tumor processes, such as naive B lymphocytes, CD8 + T lymphocytes, and plasma cells, were markedly up-regulated in the m6Acluster A. We discovered that M0 macrophages were mainly rich in m6Acluster B. Although there were no significant differences, M1 macrophages experienced a higher trend in the m6Acluster A, whereas M2 macrophages presented more fraction in the m6Acluster B. Taken together, these two m6A modification patterns were characterized by distinct profiles of infiltrating immune cells. Here, CD8A is linked to neoplasm.