BCL2 and hepatocellular carcinoma: Xue et al. reported that AB4 inhibited the growth of hepatocellular carcinoma (HCC) SMMC7721 cells and strongly induced apoptosis through manipulating the Bcl-2-caspase-3 pathway, the increased protein level of Bax and cleaved caspase-3 and the decreased level of Bcl-2 were simultaneously observed [28].