First of all, the most critical distinction was that the rate of EGFR gene G719X (p = 0.011) single mutation and G719X + S768I (p < 0.001) double compound mutation in the lung cancer patients of Yunnan eastern coal-producing regions was meaningfully more unusual than that of patients in the non-coal-producing regions, where no coal is produced and there is no substantial pollution as a result of from the coal mining. Here, EGFR is linked to lung cancer.