Epidermal growth factor receptor (EGFR) is one of the most common driver genes involved in the lung cancer mutation, which can regulate activation of both phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), and mitogen-activated protein kinase (MAPK) signaling pathways. The gene discussed is EGFR; the disease is lung carcinoma.