In the tissue subgroup, females (p < 0.001), non-smokers (p < 0.001), adenocarcinoma (p = 0.003), patients from the coal-producing areas, and non-Fuyuan county origin were found to be associated with higher EGFR gene mutation rates. In the plasma subgroup, we observed that only women (p = 0.014) and non-smokers (p = 0.011) were associated with a higher EGFR gene mutation rate (Table 4). The gene discussed is EGFR; the disease is adenocarcinoma.