Female (p < 0.001), non-smoker (p < 0.001), adenocarcinoma (p < 0.001), non-brain metastasis (p < 0.001), tissue specimens (p < 0.001), patient from the coal-producing area (p < 0.05) and non-Fuyuan country origin patients (p = 0.007) appeared to be associated with a higher EGFR gene mutation rate. This evidence concerns the gene EGFR and adenocarcinoma.