This study found that excessive G > T and T > G transversion mutations in EGFR gene were unique molecular mutation characteristics in lung cancer patients in the coal-producing areas, and the reasons may be as follows: (1) polycyclic aromatic hydrocarbons (PAHs) are the main carcinogens found in the emissions from coal-burning, which can interact with DNA to form polycyclic aromatic hydrocarbon dihydrodiol epoxide (PAH-DNA adducts). Here, EGFR is linked to lung cancer.