Furthermore, we discovered that the lung cancer patients’ EGFR gene mutation frequency in the coal-producing areas was markedly lower than that in the non-coal-producing areas, which may be associated with the differences in the primary driving genes responsible for the occurrence and development of the lung cancer in varying regions, and may be possibly related to the unique pathogenesis of the lung cancer caused by environmental pollution in Yunnan eastern coal-producing areas. The gene discussed is EGFR; the disease is lung cancer.