Further analysis showed that the factors correlated with the occurrence of ILD in patients with pSS included older age [OR=1.084, 95% CI= (1.036, 1.133), P<0.001], lower Th2 count [OR=0.947, 95% CI= (0.903, 0.994), P=0.027], increased Th1/Th2 ratio [OR=1.021, 95% CI= (1.000, 1.042), P=0.049], and positivity for anti-SSB [OR=3.620, 95% CI= (1.214, 10.791), P=0.021] and anti-Ro52 [OR=5.184, 95% CI= (2.468, 10.886), P<0.001] antibodies. Here, TRIM21 is linked to peeling skin syndrome.