PLOD1 and ovarian hyperstimulation syndrome: Excessive exposure to LH-like drugs, such as human chorionic gonadotropin (hCG), recombinant LH (rLH), or GnRH agonist, can increase the risk of ovarian hyperstimulation syndrome (OHSS), which is an iatrogenic state that can lead to adverse consequences in women undergoing IVF treatment [150, 151].