Interestingly, ssGSEA results and correlation analysis show that signaling pathways related to tumor invasion and metastasis, such as p53 signaling pathway, EMT2, EMT3, and TGF-beta signaling pathway, were mainly involved in high-risk groups, which are recognized as immunosuppressive and play a key role in tumorigenesis [26]. This evidence concerns the gene TP53 and neoplasm.