EV miR-200b and 200c and EpCAM combined with CA199 entailed a diagnostic accuracy of 97%, yielding sensitivity of 92% and specificity of 100% [31]; Therefore, the combine of novel EV biomarkers with conventional CA199 might be explored to increase diagnostic accuracy for PC and can be as noninvasive and low-cost diagnosis methods for PC screening in the future. This evidence concerns the gene EPCAM and pachyonychia congenita.