Consistent with the previous report, we observed the increased p-p38 MAPK in wild-type of murine ALI and LPS-treated macrophages, and the effects were further enhanced in STAT6-deficient murine ALI and macrophages, confirming the suppressive role of STAT6 signaling in p38 MAPK activation in vivo and in vitro. The gene discussed is STAT6; the disease is acute respiratory distress syndrome.