LHX1, encoding LIM homeobox protein 1, and ACACA, encoding acetyl-CoA carboxylase, have been proposed as potential candidate genes responsible for neurodevelopmental and epilepsy phenotypes, although there is not sufficient evidence to confirm causality to date (Hardies et al. 2013; Mefford et al. 2007). This evidence concerns the gene LHX1 and epilepsy.