Of the 30 protein coding genes with identified coding sequence or expression differences, ten had a prior association with seizure or epilepsy based on literature and database searches, including Aspa, Hic1, Nlrp1a, Nlrp1b, Pafah1b1, Smg6, Trpv1, Trpv3, Ywhae and 6330403K07Rik (Table 2). This evidence concerns the gene HIC1 and epilepsy.