The lissencephaly phenotype is attributed to deletion of PAFAH1B1, formerly known as LIS1, while disruption of YWHAE, encoding 14–3-3ε, is associated with variable structure brain abnormalities, cognitive impairment and seizures (Cardoso et al. 2000; Noor et al. 2018; Romano et al. 2020). Here, PAFAH1B1 is linked to lissencephaly spectrum disorders.