SCN1A and Dravet syndrome: Mice with heterozygous targeted deletion of Scn1a (Scn1a+/−) are a well-validated model and recapitulate core features of Dravet syndrome, including epilepsy and sudden unexpected death following a seizure in otherwise healthy animals (SUDEP-like) (Kalume et al. 2013; Miller et al. 2014; Yu et al. 2006).